The Spatial Biology Revolution in Life Sciences: Multiomic Whole-Transcriptome Digital Spatial Profiling Combined with Single-cell and Subcellular Spatial Molecular Imaging
Tuesday, October 4, 2022 11am to 12pm
About this Event
This seminar will present the latest NanoString spatial multimomics technology and informatics platforms and their high impact applications. NanoString has developed the next generation of optical barcodes that enable spatially resolved, unlimited multiplexing of proteins and mRNA (in situ) from difficult tissue samples such as formalin-fixed paraffin embedded (FFPE). The assay utilizes affinity reagents (antibodies or in situ hybridization probes) coupled to oligonucleotide tags that are either released from discrete regions of the tissue using focused UV exposure and then digitally counted at unlimited multiplex using the GeoMx Digital Spatial Profiler or imaged in 3D at single-cell and subcellular resolution using the CosMx Spatial Molecular Imaging platform. Data will be presented highlighting the utilization of the GeoMx Whole Transcriptome Atlas (up to 22,000 in situ probes for protein-coding genes) to understand healthy and diseased tissue and cancer biology. Data for the CosMx will be presented that describe the largest single-cell multiomic FFPE study ever put into the public domain (over 800,000 single cells and over 260 million transcripts) examining non-small-cell lung cancer. The CosMx enables multiomic subcellular detection in FFPE tissues with high plex and sensitivity. The AtoMx Spatial Informatics Platform will also be described, a cloud-based solution that is being launched to provide both GeoMx and CosMx data analysis in an integrated, multiuser collaborative environment with true data lakehouse architecture, which is essential for modern spatial biology studies. These spatial biology platforms will transform the study and understanding of all areas of discovery, including translational and clinical life science research.
Speaker:
Joseph Beechem, Ph.D.
Chief Scientific Officer
and Senior Vice President of Research and Development
nanoString Technologies
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