Neuromodulation of Inhibitory Microcircuits across the Lifespan and Evolution | Dr. Adam Caccavano Seminar
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1600 NW 10th Ave, Miami, FL 33136
#researchDr. Adam Caccavano is a faculty Candidate in the department of Physiology and Biophysics. His research focuses on inhibitory interneurons: how they regulate network activity, are modulated by opioids, and change across the lifespan and species. Despite being a minority cell population, interneurons exhibit a striking diversity of transcriptomic, electrophysiological, and morphological characteristics, yet key questions remain concerning a functional role for distinct subpopulations. My seminar will cover parallel efforts to describe how parvalbumin-expressing interneurons are modulated by opioids, conserved from rodents to nonhuman primates, and impaired in neurogenerative conditions including Alzheimer’s disease. Through a combination of electrophysiology, in vivo imaging, and transcriptomic analysis, my research program aims to examine how inhibitory microcircuits support computational processes underlying learning, memory, and cognition.
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