Cancer Modeling Shared Resource: Supporting Mouse Modeling, In Vivo Noninvasive Imaging, and Research Histopathology
Wednesday, April 16, 2025 1pm to 2pm
About this Event
1430 NW 11th Ave., Miami 33136
https://miami.zoom.us/webinar/register/WN_-N7L3zumQTiH96hx-hroWAThis seminar will provide an overview of the Sylvester Comprehensive Cancer Center (SCCC) Cancer Modeling Shared Resource (CMSR), which supports the design and execution of preclinical studies utilizing mouse models of human cancer. The CMSR offers an integrated array of state-of-the-art services for developing novel mouse models of human cancer and evaluating treatment response, including: 1) development and use of experimental mouse models of human cancer, including generating human and mouse cancer cell line and human patient-derived xenografts (PDXs), genetically engineered mouse models, and humanized mouse models; 2) design and implementation of novel cancer treatment protocols for pre-clinical studies using cancer models, including optimization of drug formulation and delivery, drug toxicity and efficacy assessments, sample collection and biochemical assays for pharmacokinetics and pharmacodynamics (PK/PD) studies, blood counts and chemistry analysis, and total body and/or image-guided radiotherapy; 3) diagnosis and evaluation of cancer treatment responses using a) noninvasive in vivo small animal imaging, including small animal magnetic resonance imaging (MRI), structural and functional nuclear imaging (PET/SPEC/CT), bioluminescence and fluorescence optical imaging, and high-frequency ultrasound; and b) hematology, clinical chemistry, and histopathological analysis, including tissue processing, embedding, sectioning, tissue microarrays production, H&E and immunohistochemistry staining, whole slide scanning, and digital image storage and analysis; and 4) functional genomics services for mouse modeling using CRISPR to screen sgRNA libraries and cell line production and to generate novel genetic models.
Speaker:
Daniel Bilbao, Ph.D., M.B.A.
Director, Cancer Modeling Shared Resource
Sylvester Comprehensive Cancer Center
Research Associate Professor
Pathology and Laboratory Medicine
University of Miami Miller School of Medicine
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